Studying Maliushan Nanyao Forest Park as a model, this paper studies the key technology of humanistic landscape construction of Lingnan forest-based health and wellness base combining traditional Chinese medicine culture. Inspired by the overall horse head image of the site area, the meridians, five elements, acupuncture points, prescriptions, etc. of traditional Chinese medicine are used as construction elements. Through bionic design, symbol extraction, theme elaboration, symbolic metaphor and other means of construction, combined with the integration of traditional Chinese medicine and plant landscape, the construction of roads, scenic spots and health care fields of the forest-based health and wellness base is promoted. The precise excavation of traditional Chinese medicine culture and Lingnan garden culture connotation has laid a foundation for exquisite design, construction and effect, solved the problem of culture excavation and its integrated development with scenic spots, and inherited and developed the traditional Chinese medicine culture.