The domestic wellness garden provides urban residents with access to nature and plays an important role in promoting residents' physical and mental health. Taking the olfactory experience of five senses in horticultural experience as an example, the study summarized the effects and its mechanism of aromatic plants on human health in wellness garden. In addition, the design of domestic wellness garden was briefly introduced from the aspects of positioning, design principles, functional layout and plant configuration. Furthermore, the main volatile components of 17 aromatic plants sorted out through literature, combining the interactive experience based on five senses and fragrance themed horticultural operation activity, explained the positive health function of the domestic wellness garden to the participants. This work aims to provide certain guidance and reference for enthusiasts of domestic wellness garden, and play a certain role in the promotion and popularization of the domestic wellness garden.